Abstract
Spitzer Space Telescope observations are opening a new perspective on massive star formation in the Galaxy, nearby galaxies and luminous infrared galaxies. We summarize results from an analysis of 30 Doradus Spitzer observations together with near infrared H[2] 1-0 S(1) and Br γ images and spectro-imaging observations obtained with ISO. We relate the spatial and spectral distribution of the 30 Doradus mid-infrared emission to the radiative and dynamical impact of the R136 super star cluster on the ISM structure and dust composition. This analysis provides keys to the interpretation of mid-IR observations of massive star forming regions and insight on massive clusters pre-supernova feedback on their environment.